Abstract:
Abstract. The in situ forming gel (ISG) has been developed as a controlled drug delivery system to prolong drug release. This study aims to prepare ISG system based on gamboge resin (GB) as matrix former. The various amounts of GB dissolving in dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP) were used to obtain the ISG systems and evaluated for their pH, viscosity, injectability and matrix forming. The antimicrobial activities against three strains of Staphylococcus aureus including the Methicilin Resistant S. aureus (MRSA) and Porphyromonas gingivalis were conducted. GB ISG systems exhibited good injectability with low viscosity. GB in DMSO showed a faster transformation to solid matrix compared to that in NMP. The gambogic acid (GA) content in crude GB was 33.70 ± 0.13%. The sustainable GA release from GB ISG could be attained. Thus, GB ISG exhibits the potential application as a drug delivery system for active compounds and is enable for using as a therapeutic dosage form owing to its antimicrobial activity.
… 1684307, Fluka, Switzerland) were used as solvent.
GA (lot no. PRF7080243,
Chengdu
Biopurify Phytochemicals Ltd., China) was used as standard. The media
used in antimicrobial test were Brain Heart Infusion (BHI) (lot no …
