ABSTRACT Beta sitosterol is a non-cholesterol sterol, or neutral sterol applied locally for the treatments of acute and chronic ulcers of skin and mucous membranes as well as post operative wounds. In this work β –sitosterol was prepared as topical hydrogel by cold mechanical method using different types of gel-forming polymers such as chitosan (4%, 3%, and 2%) W/W, carbapol (1.5%, 1%, and 0.5%) , and poloxamer 407( 30% and 25%)W/W. Physicochemical properties of all the prepared formulas were evaluated as a visual inspection, determination of pH, and spreadability, in addition to an in-vitro drug release. The obtained results indicated that all the different concentrations of each polymer gave a percent of drug release profile inversely proportional with the polymer concentration. F8 which contain poloxamer 407 at 25% produced higher drug release than other formulas (100% β-sitosterol release withim 3 hrs). Based on overall result, β-sitosterol can be successfully prepared as a topical hydrogel using 25% poloxamer as the best prepared formula.
… 35 INGREDIENTS AND SUPPLIERS
β -sitosterol is supplied by Changdu
biopurify phytochemica Ltd (China), Chitosan (Himedia labritory, India)
Cabopol 940(Hi Media lab.,Ltd, Mumdai, India), Poloxamer 407 (Sigma …
