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Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1

Journal name：Oncology letters
Literature No.：
Literature Url： http://www.spandidos-publications.com/ol/7/5/1711
Date publication： February 25, 2014

Abstract

Casticin is an active ingredient derived from Fructus Viticis, a traditional Chinese medicine. This study aimed to investigate the role of forkhead box O3 (FOXO3a) in breast cancer cells and examine the regulatory mechanisms of FOXO3a in response to casticin treatment of the cells by ELISA, flow cytometry, small interfering RNA (siRNA) transfection and western blot analysis. Casticin treatment induced apoptosis and reduced the expression of the transcription factor forkhead box protein M1 (FOXM1). In addition, FOXM1 repression induced by casticin treatment was associated with the activation of FOXO3a via increased mediator of

Casticin was purchased from Chengdu Biopurify Phytochemicals Ltd. (Chengdu, China).