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Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell line

Journal name：Oncology letters
Literature No.：
Literature Url： http://www.spandidos-publications.com/ol/7/6/2023?text=fulltext
Date publication：March 14, 2014

Abstact

Casticin exerts anticarcinogenic activity in several types of cancers, including human hepatocellular carcinoma (HCC). The aim of the present study was to investigate the effects of casticin, which is derived from Fructus Viticis Simplicifoliae, on the selfrenewal capacity of liver cancer stem cells (LCSCs) derived from the HCC MHCC97 cell line. The present study demonstrated that casticin significantly inhibited the proliferation of LCSCs from the MHCC97 cell line in a dosedependent manner (P<0.05), the half maximal inhibitory concentration of the parental cells and LCSCs was 17.9 and 0.5 μmol?l, respectively.

Casticin was purchased from Chengdu Biopurify Phytochemicals Ltd.