Product name: Schizandrol A
Synonym name: Wuweizichun A; Wuweizi alcohol A; Schisandrin; Schisandrol A
Catalogue No.: BP1265
Cas No.: 7432-28-2
Formula: C24H32O7
Mol Weight: 432.513
Botanical Source: Schizandra chinensis
Physical Description: Cryst.
Type of Compound: Lignans
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Schisandrin A and schisandrin B are active components of Schisandrae Fructus, has anti-inflammatory action, may act differentially on activating GST/ depleting cellular GSH and inducing an antioxidant response. [1]
Schisandrin A and Schisandrin B inhibit CYP3A activity by a mixed noncompetitive and complete inhibition, with IC(50) values of 6.60 and 5.51 microM and K(i) values of 5.83 and 4.24 microM, respectively.[2]
Schisandrin A is an MDR-reversing agent in chemotherapy for osteosarcoma, the mechanism is associated with reducing the IC50 of DOX , and increasing cleaved-PARP and cleaved-Caspase-7 levels in MG-63 cells transfected with the MDR1 expression vector.[3]
Schisandrin A and B induce OATP1B1 expression and increase its transporter activity in HepG2 cells..[4]
Schisandrin A, B, and C have certain protective effects on the oxidative damage of HaCat cells induced by H2O2. [5]
References:
[1] Kuan L P, Shan W H, Chen J, et al. Plos One, 2016, 11(5).
[2] Li W L, Xin H W, Su M W, et al. Method Find in Exp Clin, 2010, 32(3):163-9.
[3] Xia Y Z, Yang L, Wang Z D, et al. Rsc Adv, 2015, 5(18):13972-84.
[4] Guo C X, Deng S, Yin J Y, et al. Pharmazie, 2015, 70(1):29-32.
[5] Wei H. Journal of Anhui Agricultural Sciences, 2013, 41(3):1047-9.
[6] Xu XM, Li J P, Yan C, et al. Journal of Northeast Agricultural University, 2007, 14(4):323-6.
