Product name: Schisanhenol
Synonym name: Gomisin K3; Schizanhenol; Schisanhenol
Catalogue No.: BP1550
Cas No.: 69363-14-0
Formula: C₂₃H₃₀O₆
Mol Weight: 402.487
Botanical Source: " Isol. from Schizandra henryi, Schizandra chinensis and Schizandra rubiflora"
Physical Description: Powder
Type of Compound: Lignans

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.

Description:

Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals; it also has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation. Schisanhenol can protect against adriamycin induced heart mitochondrial toxicity.

References:

Fitoterapia. 2015 Mar;101:117-24.    

Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV).    

Schisanhenol (Sol) was isolated from Schisandra rubriflora, and a series of derivatives (1-16, 15a-16a, and 15b-16b) were designed and prepared by chemical modification. The curative and protective effects of these dibenzocyclooctadiene lignan analogues against tobacco mosaic virus (TMV) were evaluated. 

METHODS AND RESULTS:

Most analogues exhibited stronger protective effects than the positive control ningnanmycin. DibromoSchisanhenol (6) at 0.25mM exhibited the strongest protective activity (83.5±1.8% at 0.25mM), and 14-(3, 5-dibenzyloxy)-benzoyloxySchisanhenol (16) showed a significant curative effect (78.0±3.8% at 0.15mM) that was much stronger than that of the commercial virucide ningnanmycin. 

CONCLUSIONS:

This study is the first to demonstrate that natural dibenzocyclooctadiene lignans and analogues are active against plant viruses.    

Biomed Environ Sci. 1992 Mar;5(1):57-64.    

Protective effect of schisanhenol against oxygen radical induced mitochondrial toxicity on rat heart and liver.    

Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study. 

METHODS AND RESULTS:

The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL. 

CONCLUSIONS:

These results further confirm that SAL possesses antioxidant activity.    

Sheng Li Ke Xue Jin Zhan. 1998 Jan;29(1):35-8.    

Protective effects of schisanhenol, salvianolic acid A and SY-L on oxidative stress induced injuries of cerebral cells and their mechanisms.    

Oxidative stress may play an important role in neuronal degenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. These disorders make the elderly not being able to live normally and move freely. So it is necessary to find effective antioxidants to prevent or cure the aged persons from diseases related to neuronal degeneration.

METHODS AND RESULTS:

Schisanhenol (Sal) and salvianolic acid A (Sal A) are known antioxidants which were isolated from Chinese herbs respectively. SY-L is a totally synthetic new compound. 

CONCLUSIONS:

The results showed that Sal, Sal A and SY-L significantly protect cerebral cells from the injuries induced by oxidative stress.