Synonym name:
Catalogue No.: BP1094
Cas No.: 1802-12-6
Formula: C₃₁H₄₈O₇
Mol Weight: 532.718
Botanical Source: Aglycone from Phytolacca americana infected with Botrytis fabae and from root cultures of Phytolacca acinosa

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.

Description:

Phytolaccagenin has promising antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi, it also shows inhibitory effects on lipopolysaccharide-induced NO production, and haemolytic activities.

References:

Nat. Prod. Commun.,2010, 5(7):1013-8.    

Antifungal activity of saponin-rich extracts of Phytolacca dioica and of the sapogenins obtained through hydrolysis.  

METHODS AND RESULTS:

A saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, Phytolaccagenin, were assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi. The activity of the extract was either low or negligible, but the hydrolysate, containing the sapogenins, including Phytolaccagenin, and also pure Phytolaccagenin, showed promising antifungal potency. 

CONCLUSIONS:

Hydrolysis of a natural product extract is shown to be a useful modification leading to improved bioactivity.