Product name: Hesperetin
Synonym name: Eriodictyol 4'-monomethyl ether; Hesperitin
Catalogue No.: BP0724
Cas No.: 520-33-2
Formula: C₁₆H₁₄O₆
Mol Weight: 302.282
Botanical Source: Brickellia vernicosa, Persica vulgaris (preferred genus name Prunus), Citrus and Mentha spp.
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.[1]
Hesperetin has antioxidant activity, plays a protective role against 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress; suppresses COX-2 gene expression may be a consequence of their antioxidant activity;is a powerful peroxynitrite (ONOO-)- scavenger and promotes cellular defense activity in the protection against ONOO- involved diseases.[2-4]
Hesperetin has inhibitory effects on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K + current in human atrial myocytes.[5]
Hesperetin,has antiplatelet activity, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.[6]
Hesperetin mediates protection against doxorubicin-induced cardiotoxicity through nuclear factor-kappa B, p38, and caspase-3, indicates the protective effect of hesperetin against doxorubicin-induced cardiotoxicity.[7]

References:
[1] Aranganathan S, Selvam J P, Nalini N. Invest New Drugs, 2009, 27(3):203-13.
[2] Choi E J. Life Sci, 2008, 82(21–22):1059-64.
[3] Kim J Y, Jung K J, Choi J S, et al. Free Radical Res, 2004, 38(7):761-9.
[4] Hirata A, Murakami Y, Shoji M, et al. Anticancer Res, 2005, 25(5):3367-74.
[5] Wang H, Wang H F, Chen W, et al. Eur J Pharmacol, 2016 ,789 :98-108.
[6] Jin Y R, Han X H, Zhang Y H, et al. Atherosclerosis, 2007, 194(1):144-52.
[7] Trivedi P P, Kushwaha S, Tripathi D N, et al. Cardiovasc Toxicol, 2011, 11(3):215-25.
[8] Wan L, Sun X, Xu Z, et al. China Pharmacist, 2010, 13(08):1082-4.

HPLC of Hesperetin