Evodiamine is a chemical compound extracted from the Tetradium family of plants; it is used in some dietary supplements as its mechanism of action is suspected to be similar to that of capsaicin. It is said to act as a thermogenic as well as possess anti – infectious and anti – inflammatory properties. It may also perform in a way similar to tianeptine by increasing serotonin transporters present in the brain.

Evodiamine has been used for improving digestion problems including lack of appetite, diarrhea, vomiting, dysentery, abdominal pain, stomach ulcers, nausea and gastroesophageal reflux disease. It is also used to treat various diseases such as obesity, headache, high blood pressure as well as fluid retention. The major bioactive compounds such as Rutaecarpine, Dehydroevodiamine and Evodiamine present in Evodia species of trees could prove helpful for analgesic, gastrointestinal and cardiovascular effects due to its action on the release of calcitonin gene related peptide (CGRP).