Product name: Crocin II
Synonym name: Crocin-2
Catalogue No.: BP0407
Cas No.: 55750-84-0
Formula: C₃₈H₅₄O₁₉
Mol Weight: 814.831
Botanical Source: Crocus sativus L.; Fructus Gardeniae
Physical Description:
Type of Compound: Diterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.

The product could be supplied from milligrams to grams
Inquire for bulk scale.

Description:

Crocin has antihyperlipidemic, antidepressant , anti-inflammatory and anti-apoptotic effects. It can reduce the protein expression of iNOS and caspase-3, and increase CREB, BDNF and VGF levels in hippocampus.

References:

Braz.J.Pharm.Sci., 2015, 51(3):637-642    

A preliminary study of the anti-inflammatory and anti-apoptotic effects of crocin against gastric ischemia-reperfusion injury in rats  

The aim of the present study was to investigate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats. 

METHODS AND RESULTS:

Thirty-two male rats were randomly divided into sham, I/R, I/R + crocin pretreatment and crocin alone groups. To induce I/R lesions, the celiac artery was clamped for 30 min, and the clamp was then removed to allow reperfusion for 3 h. Crocin-pretreated rats received crocin (15 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to quantify the protein expression of caspase-3, an apoptotic factor, and inducible nitric oxide synthase (iNOS), a pro-inflammatory protein, by Western blot. Pretreatment with crocin decreased the total area of gastric lesions and decreased the protein expression levels of caspase-3 and iNOS induced by I/R injury. 

CONCLUSIONS:

Our findings showed a protective effect of crocin in gastric mucosa against I/R injury. This effect of crocin was mainly mediated by reducing the protein expression of iNOS and caspase-3.    

HNMR of Crocin II

HPLC of Crocin II