Product name: Astragaloside I
Synonym name: Astrasieversianin IV; Cyclosieversioside B; Cyclosiversioside B
Catalogue No.: BP0210
Cas No.: 84680-75-1
Formula: C₄₅H₇₂O₁₆
Mol Weight: 869.055
Botanical Source: From Astragalus membranaceus, Astragalus sieversianus, Astragalus basineri, Astragalus spinosus and Astragalus siculus
Physical Description: Powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
AstragalosideΙ(As-Ι), one of the main active ingredients in Astragalus membranaceus, As-I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway, which also activates the BMP pathway and RANK pathway, thus highlighting the As-Ιfor pharmaceutical and medicinal applications such as treating bone disease. [1]
AstragalosideΙmay protect the cerebral tissue against the free radical damage in ischemia. [2]
AstragalosideΙcan inhibit the activation of BV-2 cells induced by LPS through suppressing the activation of PI3K/Akt/NF-κB pathway, therefore, reduces the nuclear translocation of phosphorylated NF-κB, leading to the down-regulation of the gene expressions of TNF-α, i NOS and IL-1β and thus lessened the production of iNOS, TNF-α and COX-2 protein. [3]

References:
[1] Xun Cheng ?, Biaofang Wei ?, Sun L, et al. Phytother Res, 2016,7.
[2] Luo Y M. Chinese Journal of Clinical Neurosciences, 1998(03):146-8.
[3] Liu H S, Wen-Hui L I, Shen H, et al. China Journal of Traditional Chinese Medicine & Pharmacy, 2016(05).
[4] Qin J P, Yao Y, Yun L I, et al. Chinese Traditional Patent Medicine, 2008, 30(10):1468-71.

HPLC of Astragaloside I