Synonym name: alpha-mangostin; Mangostin
Catalogue No.: BP0155
Cas No.: 6147-11-1
Formula: C24H26O6
Mol Weight: 410.466
Botanical Source: Pigment from Garcinia mangostana
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams, up to kilograms.
Inquire for bulk scale.
Mangostin is a natural organic compound isolated from various parts of the mangosteen (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.
References
(1) Matsumoto K, et al.Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003; 66(8):1124-1127.
(2) Suksamrarn S, et al. Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod 2002; 65(5):761-763.
(3) Suksamrarn S, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003; 51(7):857-859.
(4) Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod 1997; 60(5):519-524.
(5) Nakatani K, et al. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen,in C6 rat glioma cells. Biochem Pharmacol 2002; 63(1):73-79.
(6) Matsumoto K, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004; 12(22):5799-5806.
(7) Williams P, et al. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res 1995; 23(2):175-184.
(8) Chairungsrilerd N, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996; 62(5):471-472.
(9) Chen SX, Wan M, Loh BN. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996; 62(4):381-382.
(10) Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.Planta Med 2002; 68(11):975-979.
(11) Moongkarndi P, et al. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 2004; 90(1):161-166.
HPLC of Alpha-Mangostin
HNMR of α-Mangostin
